{"id":10513,"date":"2025-01-31T11:50:05","date_gmt":"2025-01-31T10:50:05","guid":{"rendered":"https:\/\/www.uni.lu\/lcsb-en\/?post_type=research-groups&#038;p=10513"},"modified":"2026-07-23T12:08:45","modified_gmt":"2026-07-23T10:08:45","slug":"gene-expression-dynamics","status":"publish","type":"research-groups","link":"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/gene-expression-dynamics\/","title":{"rendered":"Gene Expression Dynamics"},"content":{"rendered":"<div class=\"section py-0 static\"><div class=\"section py-0 section wp-block-unilux-blocks-navigation-and-hero py-0\">\n    \n<div class=\"wp-block-unilux-blocks-wrapper container xl:max-w-screen-xl\"><div class=\"js-secondary-nav--sticky wp-block-unilux-blocks-secondary-navigation\" id=\"6bc66919-078e-4be4-8a56-a1589137e448\">\n    <nav\n        id=\"secondary-navigation\"\n        role=\"navigation\"\n        aria-label=\"Secondary menu\"\n        class=\"secondary-nav\"\n    >\n        <button\n            class=\"secondary-nav__button btn btn-solid--primary w-full\"\n            aria-expanded=\"false\"\n            aria-controls=\"secondary-navigation__list\"\n            title=\"The selected page is Overview\"\n            type=\"button\"\n        >\n            <span class=\"btn__name mr-auto\">Overview<\/span>\n            <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n                <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-down\" \/>\n            <\/svg>\n        <\/button>\n\n        <ul id=\"secondary-navigation__list\" class=\"secondary-nav__list\">\n            <li class=\"secondary-nav__item\">\n    <a\n        href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/gene-expression-dynamics\/\"\n        target=\"\"\n        rel=\"noreferrer noopener\"\n        class=\"secondary-nav__link isactived\"\n        aria-current=\"page\"    >\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Overview<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a\n        href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/gene-expression-dynamics\/research\"\n        target=\"\"\n        rel=\"noreferrer noopener\"\n        class=\"secondary-nav__link \"\n            >\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Research<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a\n        href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/gene-expression-dynamics\/publications\"\n        target=\"\"\n        rel=\"noreferrer noopener\"\n        class=\"secondary-nav__link \"\n            >\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Publications<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a\n        href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/gene-expression-dynamics\/people\/\"\n        target=\"\"\n        rel=\"noreferrer noopener\"\n        class=\"secondary-nav__link \"\n            >\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">People<\/span>\n    <\/a>\n<\/li>\n        <\/ul>\n    <\/nav>\n<\/div>\n<\/div>\n\n<div class=\"wp-block-unilux-blocks-wrapper max-w-screen-3xl mx-auto section py-0\">\n<section class=\"section no-padding-y wp-block-unilux-blocks-hero\">\n    <div class=\"hero hero--2 hero--overlay-top hero--overlay-bottom\">\n        \n<header class=\"wp-block-unilux-blocks-wrapper hero__header\">\n<div class=\"wp-block-unilux-blocks-wrapper hero__container\">\n<span class=\"hero__title__subject wp-block-unilux-blocks-plain-text\"><\/span>\n\n\n<h1 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"the-flow-of-information-in-cells\"\n    >\nThe flow of information in cells<\/h1>\n<\/div>\n<\/header>\n<figure class=\"wp-block-dev4-reusable-blocks-image hero__visual object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/01\/gene-expression-dynamics-group.png\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/01\/gene-expression-dynamics-group-300x225.png 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/01\/gene-expression-dynamics-group-1024x768.png 1024w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/01\/gene-expression-dynamics-group-768x576.png 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/01\/gene-expression-dynamics-group.png 1366w\"\n                style=\"object-position: 33.00% 49.00%; font-family: &quot;object-fit: cover; object-position: 33.00% 49.00%;&quot;; aspect-ratio: 16\/9; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure>\n<div class=\"wp-block-unilux-blocks-wrapper hero__body\">\n<div class=\"wp-block-unilux-blocks-wrapper hero__container\">\n<p class=\"wp-block-unilux-blocks-plain-text\">The Gene Expression Dynamics group, led by Dr Rico Schieweck, studies how mutations that affect the speed of information flow in cells are imprinted in proteins.<\/p>\n\n\n<ul class=\"wp-block-unilux-blocks-custom-buttons btn-list\">\n\n<\/ul>\n<\/div>\n<\/div>\n    <\/div>\n<\/section><\/div>\n<\/div>\n\n\n<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"a-glimpse-into-our-research\"\n    >\nA glimpse into our research<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"translation-as-the-gene-gate-to-the-proteome\"\n    >\nTranslation as the &#8220;gene gate&#8221; to the proteome<\/h3>\n\n\n\n<p>We study the speed at which ribosomes read along mRNAs. This so-called ribosome dynamics regulates key steps in gene expression such as RNA stability, protein levels and their folding. We are combining translatomics, interactomics and visual proteomics experiments to identify protein and RNA interactors of ribosomes that regulate their dynamics during stem cell differentiation.<em> <\/em><\/p>\n\n\n\n<ul class=\"wp-block-unilux-blocks-quick-link-underline\">\n    \n<li class=\"wp-block-unilux-blocks-quick-link-underline-item\">\n    <a\n            href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/gene-expression-dynamics\/research\"\n            class=\"wp-block-unilux-blocks-anchor\"        target=\"_blank\"\n>\n    \n<span class=\"hero__title__subject wp-block-unilux-blocks-plain-text\">Research<\/span><svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--external-link \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--external-link\"><\/use><\/svg><\/a>\n<\/li>\n\n<li class=\"wp-block-unilux-blocks-quick-link-underline-item\">\n    <a\n            href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/gene-expression-dynamics\/publications\"\n            class=\"wp-block-unilux-blocks-anchor\"        target=\"_blank\"\n>\n    \n<span class=\"hero__title__subject wp-block-unilux-blocks-plain-text\">Publications<\/span><svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--external-link \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--external-link\"><\/use><\/svg><\/a>\n<\/li>\n<\/ul><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/01\/gene-expression-dynamics-group_Overview_LCSB_website.jpg\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/01\/gene-expression-dynamics-group_Overview_LCSB_website-300x225.jpg 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/01\/gene-expression-dynamics-group_Overview_LCSB_website-1024x767.jpg 1024w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/01\/gene-expression-dynamics-group_Overview_LCSB_website-768x575.jpg 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2025\/01\/gene-expression-dynamics-group_Overview_LCSB_website.jpg 1399w\"\n                style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: cover; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 16\/9; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure>\n\n\n<p><em>The speed of ribosomes is influenced by the levels of aminoacyl-tRNAs, the stoichiometry of translation factors and the sequence elements embedded in transcripts.<\/em><\/p>\n<\/div>\n<\/div>\n<\/div><\/section>\n\n\n\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"this-research-group-is-part-of\"\n    >\nThis research group is part of<\/h2>\n\n\n\n<ul class=\"wp-block-unilux-blocks-button-list-v2\">\n<li class=\"wp-block-unilux-blocks-button-list-item-v2\"><a class=\"quick-link\" href=\"https:\/\/www.uni.lu\/lcsb-en\/\" target=\"_blank\" role=\"link\" rel=\"noopener\" tabindex=\"0\"><span class=\"quick-link__container\">\n<div class=\"wp-block-unilux-blocks-block-inserter quick-link__img\"><figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"Luxembourg Centre for Systems Biomedicine Logo\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/uni-centre-lcsb-no-baseline.svg\"\n                    style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: cover; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 1\/1; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure><\/div>\n\n\n\n<span class=\"quick-link__name wp-block-unilux-blocks-plain-text\">Luxembourg Centre for Systems Biomedicine (LCSB)<\/span>\n\n<svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg><\/span><\/a><\/li>\n<\/ul>\n\n\n<div class=\"wp-block-unilux-blocks-spacer is-spacer-size-lg\"><\/div><\/div><\/section>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>The Gene Expression Dynamics group, led by Dr Rico Schieweck, studies how mutations that affect the 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